Speaking in March 2010 to noted UK urban writer Pete Lewis - Deputy Editor of the award-winning Blues & Soul - Cypress Hill emcee B-Real explained how the song 'Rise Up' became the title track to its accompanying album: "Sen Dog and myself had been working on the album for quite some time. And we got to a point where we were like 'Maybe we should call Tom Morello to see if he'd be interested in taking a listen to this album and perhaps contributing to it'... And so fortunately Tom - who's a friend of ours - listened, liked what he heard - and ended up giving us a great TRACK! And, though at the time we had a few possible album titles prepared that we liked, at that point none of them had actually STUCK. But then, once we recorded Tom's song and came up with the title for it - 'Rise Up' - we knew instantly that had to be the title for the whole RECORD! Because it basically summed up what we were DOING! Like we've been doing this for so long, and here we are now getting back up and trying to get this Cypress Hill movement on the roll again!"
The music video was filmed in Los Angeles, California. It begins with a news cast describing a riot. When this news cast ends it shows Tom Morello his guitar. This is followed by a scene featuring a girl sitting down with a gas mask on watching several televisions. B-Real's first verse is featured on several televisions before Sen Dog's verse in which the scene ends and it focuses on various shots of Cypress Hill and Tom Morello. At the end it shows the band playing on top of giant lettering stating the song's name in front of various fans.